APOE and connective tissue disorder: Furthermore, although some genetic arterial diseases, such as Loeys-Dietz syndrome, Marfan syndrome, Aneurysm-osteoarthritis syndrome, can manifest as aortic or carotid artery tortuosity through the remodeling of vascular connective tissue (34), there are currently a lack of reports linking ApoE gene polymorphisms to these genetic connective tissue disorders.