Additionally, SSG effectively impeded lung metastasis in a mouse model of lung cancer (Lewis lung cancer [LLC] xenograft), aligning with the fact that immature myeloid cells, including CD11b+ Ly6C+ Ly6G− monocytes and CD11b+ Ly6C+ Ly6G+ granulocytes, significantly contribute to pre-metastatic niche formation in the lungs. This evidence concerns the gene ITGAM and lung cancer.