In brief, cinnamaldehyde, puerarin, FZKA, TFAN, QDN, and XJD could notably suppress the growth of lung cancer cells through modulation of key signaling pathways, including Wnt/β-catenin, mitochondrial apoptosis, Bcl-2/STAT3, and Akt, thus further consolidating their potential as TCM-based therapeutic strategies. Here, AKT1 is linked to lung cancer.