Uveitis could be induced by immunization with retinal soluble antigen (S-Ag), interphotoreceptor retinoid-binding protein (IRBP) or their peptide derivatives (PDSAg from S-Ag and R14 from IRBP) in Complete Freund’s Adjuvant (CFA) as well as by the transfer of activated, antigen-specific T cells. This evidence concerns the gene RBP3 and uveitis.