Notably, CAF-derived exosomes have been found to carry antioxidant molecules (e.g., miR-522) or regulatory signals that suppress the expression of lipid peroxidation-related genes (e.g., ALOX15), reducing the accumulation of lipid peroxidation products and thereby significantly mitigating ferroptosis effects and promoting chemoresistance in tumor cells (47). The gene discussed is ALOX15; the disease is neoplasm.