IL1B and rheumatoid arthritis: were the first to report that exosomes derived from bone marrow MSCs transfer miR-150-5p to the joint cavity, reversing the migration and invasion of RA fibroblast-like synoviocytes (RA-FLSs) induced by pro-inflammatory factors such as IL-1β, TGF-β, and TNFα by inhibiting the expression of the target genes MMP14 and VEGF, thereby alleviating RA (10).