Similarly, a study of 29 anti-Yo positive breast carcinoma patients revealed that all had at least one genetic alteration such as mutations (62.5%), amplifications (61.5%), or 17q gains (38.4%) in the CDR2L/CDR2 genes, which also contributed to paraneoplastic cerebellar degeneration (69). This evidence concerns the gene CDR2 and cerebellar degeneration.