Importantly, the patient’s ANA positivity—which are commonly associated with systemic lupus erythematosus, Sjögren’s syndrome, and systemic sclerosis—warrants regular monitoring of ANA titers and prompt evaluation for symptoms such as facial rash, recurrent oral ulcers, severe alopecia, polyarthralgia, dry mouth or eyes, frothy urine, or unexplained fever (23, 24). Here, BTG3 is linked to systemic lupus erythematosus.