Importantly, the patient’s ANA positivity—which are commonly associated with systemic lupus erythematosus, Sjögren’s syndrome, and systemic sclerosis—warrants regular monitoring of ANA titers and prompt evaluation for symptoms such as facial rash, recurrent oral ulcers, severe alopecia, polyarthralgia, dry mouth or eyes, frothy urine, or unexplained fever (23, 24). This evidence concerns the gene BTG3 and Oral ulcer.