SIRT1 and asthma: Human peripheral blood mononuclear cells (PBMCs) from patients with severe asthma show reduced SIRT1 protein expression and activity and increased Th2 cytokine expression (74); and treatment of HUT78 T-cells with SIRT inhibitors can increase GATA Binding Protein 3(GATA-3) acetylation and IL-4 and IL-13 expression (75).