In addition, the susceptibility of primary B-ALL cells to NK cell activity was also shown to be dependent on the NKG2D-NKG2DL axis (20, 27), suggesting that CD19/NKG2DL multispecific CAR T-cells might represent an interesting approach to prevent CD19 antigen escape in B-cell malignancies. The gene discussed is CD19; the disease is acute lymphoblastic leukemia.