SHROOM3 and atrial fibrillation: We identified 11 distinct loci harboring multiple genes significantly associated with AF risk (p < 0.05), including CEP68 (2p14), FKBP7 (2q31), SPATS2L (2q33.1), UBE2D3 (4q24), CAMK2D (4q26), SLC2A9 (4p16.1), SHROOM3 (2q31.2), CCDC158 (4q21.1), CCNT2, RPL9, and FBXL5 (Table S4).