While other atypical Parkinson’s syndromes (APS), such as PSP, multisystemic atrophy (MSA), and corticobasal ganglion syndrome (CBS), are characterized by a marked increase in NfL level of CSF due to myelin axonal involvement, this pathological process is not typical in the early stages of PD (von Widekind et al., 2020). This evidence concerns the gene NEFL and Parkinson disease.