In contrast, Alzheimer's disease (AD) is characterized behaviorally by progressive memory impairment, confusion, loss of cognitive abilities, and various brain changes, including abnormal protein accumulation [amyloid-beta and tau (Braak et al., 1994; Braak and Braak, 1991)], inflammation (Akiyama, 2000), and neuron and synapse loss (Tzioras et al., 2022). This evidence concerns the gene MAPT and Alzheimer disease.