CRP-to-albumin ratio (CAR), a biomarker related to inflammation and nutrition, has been demonstrated as a prognostic factor in various cancers including colorectal cancer (Ruan et al., 2023b), gastric cancer (Sakai et al., 2020), pancreatic cancer (Fujiwara et al., 2018), esophageal cancer (Ishibashi et al., 2018), and ovarian cancer (Komura et al., 2021). The gene discussed is ALB; the disease is esophageal cancer.