IGF2BP2 and esophageal squamous cell carcinoma: To explore the clinical relevance of LINC02820 and IGF2BP2 in ESCC, we first analyzed their expression patterns in our sequencing dataset and found that IGF2BP2 expression were significantly elevated in ESCC tumors compared with paired adjacent normal tissues (Figure 5I), which was further validated in both TCGA (Figure 5J) and GSE130078 datasets (Figure 5K).