Further analysis using Western blotting and IHC confirmed that CVB‐D promoted the phosphorylation of p38MAPK, suggesting its activation of the LIF/p38MAPK/p62 signaling pathway, promoted the expression of p62 protein, and promoted mitophagy in HCC (Figure 7H,I and Figure S7H,I). The gene discussed is LIF; the disease is hepatocellular carcinoma.