In spite of the widespread involvement of LIF in the STAT3 pathway found in oncological studies, other oncogenic pathways associated with LIF exist, for instance, the LIF/p‐AMPK signaling pathway in HCC [38], and the LIF/STAT3/ID1/ MDM2 signaling pathway in colorectal cancer [45]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.