Furthermore, western‐blotting and IHC staining of tissues from the HCC orthotopic tumor group showed decreased Cyclin D1 and Snail levels and enhanced cleavage of E‐cad, p27, PINK1, and p62 in the CVB‐D group (Figure 7B and Figure S7B–D), which indicated that CVB‐D could significantly inhibit the development of HCC in vivo and is devoid of toxicity by HE staining (Figure S7E). Here, CCND1 is linked to neoplasm.