This result is not difficult to understand, vascular endothelial growth factor (VEGF) is currently recognized as an important mechanism of pathological neovascular proliferation in ROP (19), HDP can lead to decreased expression of VEGF antagonist receptors (20), and elevated VEGF expression in the maternal environment ultimately interferes with fetal retinal vascular development, making them more susceptible to ROP after birth. The gene discussed is VEGFA; the disease is retinopathy of prematurity.