In this study, two issues are worth noting: (a) stroke was defined per ICD-10 system to encompass diagnoses ICD-10 of: I60–I69; and (b) the same group of researchers24 could not replicate these findings in subsequent research, demonstrating lack of association (or even a marginally negative association in unadjusted analyses) between IFN-b and the risk of stroke in a recent and significantly larger study with longer follow-up, as detailed previously. This evidence concerns the gene IFNB1 and stroke disorder.