For instance, mutations in DNMT3A, TET2, IDH1 and IDH26, 7, 8 are implicated in adult acute myeloid leukaemia (AML), while paediatric AML is commonly driven by gene changes in MLL, RUNX1, CBFB and FLT3.9, 10. Here, RUNX1 is linked to acute myeloid leukemia.