According to basic research results, the mechanisms through which naringenin reduces TC and TG levels in NAFLD/NASH rodent models are outlined below: (i) The key regulatory enzyme that inhibits cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase is involved in lipid metabolism (99). This evidence concerns the gene HMGCR and metabolic dysfunction-associated steatotic liver disease.