In hepatocellular carcinoma (HCC), FOXC1 facilitates C-C motif chemokine ligand 2 (CCL2) or C-X-C motif chemokine receptor 1 (CXCR1) expression to drive tumor-associated macrophage infiltration and metastasis [22]. The gene discussed is CXCR1; the disease is hepatocellular carcinoma.