Meanwhile, a novel OGT-570aa isoform encoded by ecircOGT was able to inhibit the interaction of OGT and FOXC1, thus promoting ferroptosis and decreasing tumorigenesis and aggressiveness (Fig. 8K), which suggests that targeting the ecircOGT/OGT/FOXC1 axis could be an option for NB treatment. The gene discussed is OGT; the disease is neuroblastoma.