ASNS and neuroblastoma: Based on analysis using the O-GlcNAcPRED-DL tool [37], mutation of the 8th serine, but not of the 68th threonine, of FOXC1 led to a decrease of its O-GlcNAcylation, transcriptional activity, and enrichment on target genes, resulting in the down-regulation of ASNS and GPT2 in NB cells (Fig. 5I to L).