The transient formation of immune complexes between vaccine antigen and the newly formed antibodies can lead to a false-positive result, especially in individuals with impaired immune complex clearance, such as HD patients. Another proposed mechanism involves the partial homology between influenza hemagglutinin and HIV-1 envelope transmembrane proteins (gp41/gp120), which share molecular similarity, thus resulting in the subsequent cross-binding of influenza vaccine-induced antibodies to HIV antigens [11,13]. Here, ITIH4 is linked to influenza.