Additionally, PD-1 inhibition has been associated with increased production of pro-inflammatory cytokines, particularly interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), which can disrupt the function of pituitary cells and contribute to irreversible hormone deficiencies [8]. The gene discussed is IFNG; the disease is hyperinsulinemic hypoglycemia, familial, 4.