CASR and isolated hemihyperplasia: Recently, polymorphisms in some genes that encode certain proteins involved in tubular calcium or phosphate reabsorption (CASR, SLC34A1, SLC34A4, CLDN14, CaSR, TRPV6, TRPV5), or in the prevention of precipitation of calcium salts (CaSR, MGP, OPN, PLAU, UMOD), have been associated with IH and kidney stones [12,22,49,85-87].