Many surface molecules, including GPC3, asialoglycoprotein receptor (ASGP-R), transferrin receptor (TfR), AF20 antigen, somatostatin receptor (SSTR), and lysosome-associated protein transmembrane 4β (LAPTM4B), are highly expressed on the surface of HCC cells in comparison to normal hepatocytes. The gene discussed is LAPTM4B; the disease is hepatocellular carcinoma.