His ocular history included a pars plana vitrectomy combined with heavy silicone oil tamponade following a traumatic retinal detachment three years earlier, alongside pan-retinal photocoagulation, anti-vascular endothelial growth factor and steroid injections for his diabetic eye disease. Spontaneous closure of the full-thickness macular hole within three months not only improved visual acuity from 1.04 LogMAR to 0.68 LogMAR but also illustrates the retina's natural reparative capabilities. The gene discussed is VEGFA; the disease is retinal detachment.