ART3 and cancer: The centSIRT6 demonstrated superior suppression of long interspersed nuclear element-1 (LINE1) retrotransposons, enhanced stimulation of DNA double-strand break repair, and a more robust ability to kill cancer cells.16, -18 Interestingly, centSIRT6 showed weaker deacetylase activity than its wild-type counterpart but higher mono-ADP ribosyl transferase activity.16