ART3 and cancer: Meanwhile, mono-ADP-ribosylation plays an important role in the regulation of diverse cellular pathways and is closely related to general health and the development of numerous diseases.43 The increased mono-ADP ribosyl transferase activity of centSIRT6 could be particularly advantageous in modulating processes such as cell cycle progression, DNA damage repair, inflammatory responses, and defence mechanisms against viral infections and cancer, among others.