To determine the parameters related to treatment resistance, the baseline levels of parameters―obesity (body mass index), metabolic factor (visceral fat, controlled attenuation parameter), diabetes mellitus (DM) (glycated hemoglobulin (HbA1c), fasting immunoreactive insulin), lipid metabolism (triglyceride), and hepatitis (ALT)―were compared between treatment-sensitive group 1+group 2 and treatment-resistant group 3. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.