In particular, several alterations are highly specific to a certain subtype, such as RHOA G17V and IDH2 mutations in nTFHLs, ALK fusions in ALCL, DDX3X and MSN mutations in ENKTL, PRKCB, CIC, and CCR4 mutations in ATLL. This evidence concerns the gene CCR4 and adult T-cell leukemia/lymphoma.