Conversely, subtype-specific alterations, such as RHOA G17V and IDH2 R172 mutations in nTFHLs; ALK fusions in ALCL; DDX3X and MSN mutations in ENKTL; and PRKCB, CIC, and CCR4 mutations in ATLL. Here, CCR4 is linked to adult T-cell leukemia/lymphoma.