AKT1 and prion disease: In the SVG vs. CG comparison, DEGs were significantly enriched in 15 KEGG pathways, including Ribosome, Toll-like receptor signaling pathway, Parkinson disease, NF-kappa B signaling pathway, Linoleic acid metabolism, JAK–STAT signaling pathway, Proteasome, Prion disease, PI3K-Akt signaling pathway, DNA replication, Viral protein interaction with cytokine and cytokine receptor, Retrograde endocannabinoid signaling, ECM-receptor interaction, Cytokine-cytokine receptor interaction, and Arrhythmogenic right ventricular cardiomyopathy (Figure 5C).