TNF and early-onset autosomal dominant Alzheimer disease: The DEGs identified in the VG vs. CG comparison were significantly enriched in 13 KEGG signaling pathways, including Ribosome, JAK–STAT signaling pathway, Huntington disease, NF-kappa B signaling pathway, Prion disease, Toll-like receptor signaling pathway, TNF signaling pathway, Oxidative phosphorylation, Alzheimer disease, Proteasome, Retrograde endocannabinoid signaling, NOD-like receptor signaling pathway, and Diabetic cardiomyopathy (Figure 5A).