ST22 isolates from infections had aminoglycoside (i.e., aac(6′)-Ie/aph(2′′)-Ia), erythromycin [i.e., erm(C)], trimethoprim (i.e., dfrC) resistance genes, and mutations in quinolone targets (i.e., gyrA_S84L / parC_S80F) that were not present in ST22 isolates from nasal colonizations. Here, ETV5 is linked to infection.