HDAC9 and leishmaniasis: Histone deacetylases (HDAC) are critical regulators ofchromatin structure and represent potential drug targets for leishmaniasis.This study evaluated three HDAC inhibitors (HDACi), TH60, TH74, andTH85, in BALB/c mice infected with L. braziliensis, comparing their efficacy to the standard treatment, glucantime.Two doses were tested, and lesion size, parasite load, kidney andliver enzyme levels, and histopathological analyses were carried out.HDACi effectively reduced lesion size and parasite presence, withlower toxicity and fewer organ alterations than glucantime.