PTEN and neoplasm: CN losses were commonly detected in WNT8B (60% patient tumours, 50% cell lines, 66% PDX models), RB1 (60% patient tumours, 50% cell lines, 66% PDX models) and PTEN (60% patient tumours, 0% cell lines, 100% PDX models) with notable losses also seen in CDKN2A (25% patient tumours, 75% cell lines, 66% PDX models; Fig. 1A).