CD69 and ANGPTL2 have previously been studied in the context of immunomodulation in CKD/CVD.13–15 CKMT1A/B is central for cellular energy homeostasis by forming phosphocreatine which serves as fuel for tissues with high energy demand.16 RAB6 is involved in vesicular traffic in secretory pathways and mediates NPY exocytosis in vitro. This evidence concerns the gene CKMT1A and chronic kidney disease.