NR3C2 and kidney disorder: Elevated plasma NPY has been associated with adverse cardiac remodelling8,9 and kidney disease progression.10 Mechanistic work demonstrated that knockout or blockade of NPY protects from albuminuric kidney disease.10 It has also been suggested that NPY can directly modulate adrenal aldosterone release,11 but not thus far that altered aldosterone or MR blockade affect circulating NPY.