At baseline, the median estimated glomerular filtration rate (eGFR) was 65.3 mL/min/1.73 m2 (interquartile range, 49.4–81.3), >97% of subjects were albuminuric (urinary albumin-to-creatine ratio ≥ 30 mg/g), and overall comparable to the parent trial.3 17.3% of patients were hospitalized for cardiovascular diseases (CVD) and 34.6% had a history of CVD prior to randomization. The gene discussed is ALB; the disease is cardiovascular disorder.