To explore whether CD248 is involved in the pathophysiology of aortic aneurysms, we first investigated its expression in patients with aortic aneurysm and compared Ang II (1000 ng/kg/min)‐infused mice fed a high‐cholesterol diet (Ang II+Chol) against untreated conrtol mice. Here, CD248 is linked to aortic aneurysm.