Within the tau PET clusters, the posterior tau PET cluster showed pronounced atrophy in the occipital and parietal regions, in the medial temporal lobe and the insula; the limbic tau PET cluster mainly in parietal, temporal and frontal brain regions; the MTL-sparing tau PET cluster pronounced in parietal and temporal areas; and the left temporal tau PET cluster in temporal and parietal brain regions (left > right) (Fig. 1B). Here, MAPT is linked to Atrophy.