MAPT and Atrophy: Comparing the tau longitudinal PET uptake among atrophy clusters, we found mainly more rapid increase in diffuse atrophy cluster than MA and LP clusters in a widespread fashion, while the differences in the left frontal pole and left insular cortex (diffuse > LP) as well as differences in the right entorhinal cortex, pars triangularis, and right rostral middle frontal cortex (diffuse > MA).