Among severe TRAEs, 3 (5.66%) patients had grade 3-4 liver injury with increased AST/ALT, 2 (3.77%) had grade 3-4 neutropenia, 1 (1.89%) had grade 3-4 leucopenia, and 1 (1.89%) had vitiligo. This evidence concerns the gene GPT and Decreased total neutrophil count.