IL1R1 and occult macular dystrophy: Owing to the cytosolic domain of significant homology, IL1R1, together with TLR, belonged to the same IL-1R/TLR receptor superfamily and activated similar downstream including the NF-κB signaling pathway.49,50 In this study, enriched reduction of IL1R1 expression was discovered in the OMD-overexpressed hDPSCs.