APOE and atherosclerosis: To investigate the defensive effects of ZXYF against dyslipidemia and atherosclerosis, ApoE−/− mice were fed HFD to induce AS and treated with daily doses of ZXYF (Low 3.25 g/kg and 6.50 g/kg) or atorvastatin (10 mg/kg) for 8-week (Fig. 2A).