GSK3B and memory: Hence, the activation of GSK-3β in the oAβ1−42-treated mice, caused at least partially by the altered proteins revealed by MALDI imaging analysis, could underlie the transformation of HFS-induced LTP into LTD previously described ex vivo [14, 18] and in vivo [15, 16] and therefore the memory deficits present in this murine model [18].