Among those 14 proteins analyzed, our data showed a downregulation of RCAN1 and Crebbp, and an upregulation of GluR5, mGluR6, Igfbpl1 and Neurod2 in the hippocampus of both male and female mice after a single oAβ1−42icv. injection, a well characterized model of early AD-like amyloidosis [18]. This evidence concerns the gene CREBBP and Alzheimer disease.