Based on an extensive review of existing literature, 14 proteins related to synaptic plasticity and/or AD were selected to further study: RCAN1, Crebbp, GluR5, mGluR6, Igfbpl1, Neurod2, SAA3, Hivep2, Lsr, CaMKK2, M1 mAChR, Dab1, Pianp and Ppp3r1. The gene discussed is GRIK1; the disease is Alzheimer disease.