Compared with women with a normal BMI, obese grade 1 (BMI ≤ 35 kg/m2) and obese grade 2 + 3 (BMI > 35 kg/m2) women had an increased risk of ER + /PR + BC by 52% and 86%, respectively, suggesting that obesity increases the risk of BC significantly in obese women, especially in obese grade 2 + 3 women [6]. This evidence concerns the gene ESR1 and breast cancer.