Concurrently, in the study by da Cunha, PA et al., an analysis of 100 BC patients and 148 healthy women from Santa Catarina, Brazil, found that the interaction between Obesity Associated gene (FTO) and melanocortin 4 receptor gene (MC4R) polymorphisms is strongly associated with BC. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.