We analyzed allelic expression patterns in cell lines from a variety of cancer histologies, some of which have frequent amplifications or deletions of different genome regions containing imprinted genes, e.g., ANO1 at 11q13, multiple imprinted genes at 20q11-q13.32, RB1 at 13q14.2, and genes in other regions [34, 63, 76, 97, 134, 135, 162–164]. The gene discussed is RB1; the disease is cancer.