Biallelic expression of several isoforms of CDC27, which encodes a core component of the Anaphase-promoting complex/cyclosome regulating the cell cycle, was associated with sensitivity to the PARP inhibitor PARP_9495, the topoisomerase I inhibitor SN-38, and the Aurora kinase inhibitor SNS-314, consistent with earlier reports of regulation of the CDC27 gene or protein by PARP inhibitors and by SN-38, of direct interactions between CDC27 and Aurora kinase B, and of CDC27 importance in cancer and in response to treatment, notably to DNA damage and mitotic checkpoint inhibition [150–154]. Here, CDC27 is linked to cancer.