Additionally, one H19 isoform, ENST00000436715, whose monoallelic expression was significantly associated with elevated expression (Additional file 25: Table S14), has been implicated in important developmental and cancer-related processes, as it is upregulated in human bone marrow mesenchymal stem cells during osteogenic differentiation and is among most dysregulated lncRNAs in gallbladder cancer [172, 173]. This evidence concerns the gene H19 and gallbladder cancer.