For example, the tyrosine phosphatase mediates transcription (30), functions in DNA damage response (31, 32, 33), regulates the cytoskeleton (23, 34), promotes mitotic progression and centrosome maturation (35, 36), induces angiogenesis (21, 37, 38), regulates estrogen receptor beta signaling (30), promotes Myc stabilization (8, 39), increases tumor metastasis (23, 40), and maintains progenitor cell populations (35). The gene discussed is MYC; the disease is neoplasm.