Consistent with the mechanisms observed in MAFLD mice, RT-qPCR and western blot analyses confirmed that HDA downregulated XBP1 and Hrd1 expression whileupregulating Nrf2, SLC7A11, and GPX4 in the HepG2 steatosis model, thereby inhibiting ferroptosis (Figure 7(b–c)). The gene discussed is XBP1; the disease is steatosis.