This study aimed to investigate the proportion of the mutated phenotype of the main AIDS-related polymorphisms, CCR5-Delta32, CCR2-64I, and SDF1-3′A among HIV-infected and uninfected individuals in Luanda, the capital city of Angola, a country located in sub-Saharan Africa, in order to contribute to an understanding of the host genetic factors that influence HIV susceptibility and progression in this population and thus provide valuable information to adapt preventive and therapeutic strategies for the management of HIV/AIDS in Angola and similar regions in Africa. This evidence concerns the gene CXCL12 and AIDS.