A study by Zhang et al., 2020 demonstrated the STING dependent coagulation pathway activation in association with calcium mediated Gasdermin D (GSDMD) and the improval of bacteremia with Escherichia coli and Streptococcus pneumoniae infection while inhibiting the STING-GSDMD pathway using using pharmacological inhibitors [107]. This evidence concerns the gene STING1 and bacterial infectious disease with sepsis.