TIMP1 and hyperhomocysteinemia: In hepatitis C, activating the inhibitor of metalloproteinase TIMP-1(Tissue inhibitor of metalloproteinases-1) and decreasing the antiviral impact of interferon through hypomethylation of STAT1(Signal transducer and activator of transcription 1), hyperhomocysteinemia may contribute to hepatic fibrogenesis.