Martos et al., 2020 showed significant levels of neutrophil markers (cell free DNA, MPO and calprotectin) and lower level of natural anticoagulant activated protein C (APC) and its genetic regulators (THBD-c.1418 T and, PROCR-H3, PROCR-H1) in patients with venous thromboembolism [63]. The gene discussed is PROCR; the disease is venous thromboembolism.