Among these variants, SLC28A3-rs7853758, RARG-rs2229774, and the union of P2RX7-rs208294 and P2RX7-rs3751143 variants represent the most consistent findings, showing strong and significant associations with cardiomyopathy following childhood cancer treatment, including anthracycline; these associations have been successfully replicated in patients from external cohorts [20, 21, 23, 39]. Here, P2RX7 is linked to cardiomyopathy.