RARG and cardiomyopathy: Patients carrying the RARG-rs2229774 variant have an increased risk of cardiomyopathy ; the RARG gene is involved in the transcriptional regulation of an enzyme, Topoisomerase-2β, which is involved in DNA replication and repair, and that interacts with doxorubicin in cardiac tissues, leading to cardiomyocyte apoptosis and heart failure in mice [14].