Patients carrying ROBO2-rs17736312-AA genotype and exposed to anthracyclines >250 mg/m2 demonstrated a 2.2-fold (95% CI: 1.2–4.0, p = 0.009) higher risk of CHF compared to patients carrying at least one G allele and exposed to less than 250 mg/m2 of anthracyclines [38]. Here, ROBO2 is linked to congestive heart failure.