Endothelial CXCR2 deficiency led to CXCR2 desensitization by decreased CXCR2 expression on neutrophils (Supplementary Fig. 8M) and subsequently impaired neutrophil migration 24 h after the induction of pneumonia (Supplementary Fig. 8N-P). The gene discussed is CXCR2; the disease is pneumonia.