Additionally, we utilized the quantitative phosphoproteome data of TBK1 knockout cancer cells to explore the effect of TBK1 on syntenin-1 phosphorylation and observed that the phosphorylation level of syntenin-1 serines was notably downregulated in TBK1 knockout cells compared to wild-type cells (Fig. 6I) (39). This evidence concerns the gene TBK1 and cancer.