ROS produced by acute pancreatitis stimulate NF-κB, leading to excessive release of cytokines such as interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-18 (IL-18), interleukin-6 (IL-6), and TNF-α [81]. This evidence concerns the gene IL2 and acute pancreatitis.