ROS produced by acute pancreatitis stimulate NF-κB, leading to excessive release of cytokines such as interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-18 (IL-18), interleukin-6 (IL-6), and TNF-α [81]. The gene discussed is NFKB1; the disease is acute pancreatitis.