CD4 and neoplasm: Compared with the tumor regions, higher CD4 + and CD8 + T cell densities were observed in the stromal area (183.95/mm2 vs. 40.03/mm2, p < 0.001; CD4 + : 61.80/mm2 vs. 29.57/mm2, p < 0.001; CD8 +, Fig. 2A).