CD4 and neoplasm: T cells closer to the tumors (NR vs 9 months, p < 0.001, CD4; NR vs 11.4 months, p < 0.001, CD8) and more TILs around the tumor cells (NR vs 9.4 months, p < 0.001, CD4; NR vs 12.6 months, p = 0.011, CD8, Fig. 6G) prolonged patient overall survival, even if LAG3 expression was considered, and CD8 + T cells possessed a proximate effect as well (NR vs 13.2 months, p = 0.007, Nearest distance; NR vs 12.6 months, p = 0.003, Average cells, Fig. 6H).