CD4 and neoplasm: In subsequent studies of on-treatment tissues, we found results largely consistent with those obtained in baseline, namely that LAG3 + T cells density negatively correlated with the nearest distance to tumor and positively related to average number of T cells around tumor cells (Nearest distance: Spearman ρ = −0.372, p = 0.012, CD4; Spearman ρ = −0.253, p = 0.094, CD8, Fig. 6F; Average cells: Spearman ρ = 0.511, p < 0.001, CD4; Spearman ρ = 0.409, p = 0.005, CD8, Fig. S2 C).