LAG3 and cancer: We found that the density of LAG3 + T cells was correlated with CD4 + or CD8 + T cells in the local tumor tissues of untreated patients, the correlation was mainly in the stromal zones (Spearman ρ = 0.384, p = 0.009, CD4 +; Spearman ρ = 0.300, p = 0.045, CD8 +, Fig. 2D), rather than among the infiltrating T cells in the tumor area, the core of the cancer nests consisting of PANCK-staining cells.