For the role of LAG3 in CD4 + T cells, it has been reported that LAG3 in conventional CD4 + T cells (Tconvs) from the peripheral blood of patients with head and neck squamous cell carcinoma may restrict the local anti-tumor immune response of CD8 + T cells by inhibiting a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) [20]. Here, ADAM10 is linked to head and neck squamous cell carcinoma.