CD4 and neoplasm: Another animal study on tumor immunology found that while LAG3 blockade did not increase T cell infiltration, it doubled the proportion of tissue-localized TCRαβ + CD4-CD8-NK1.1- innate αβ T-cells (iαβTs)—these IL17-producing immune cells have been shown to possess significant anti-tumor effects [32, 35, 40].