We also found that the percentage of LAG3 in CD4 + and CD8 + T cells negatively related to the nearest distance between tumor and corresponding subsets T cells (Spearman ρ = −0.488, p < 0.001, CD4; Spearman ρ = −0.302, p = 0.046, CD8, Fig. 6D), but there was no evidence to show the relationship between LAG3 positive ratio and the average number of peritumor T cells. Here, CD4 is linked to neoplasm.