Although the density and percentage of LAG3 + T cells were uniform throughout the tissues, both CD4 and CD8 positive T cells in the tumor portion have higher Ki67 and IFN-γ expression rates(2.46% vs 0.71%, p = 0.017, Ki67 in CD4 + T; 1.89% vs 1.20%, p = 0.067, Ki67 in CD8 + T; 14.91% vs 3.41%, p < 0.001, IFN in CD4 + T; 30.22% vs 5.88%, p < 0.001, IFN in CD8 + T, Fig. 2C), even though these cells occupied a lower density compared to the stromal part. Here, CD4 is linked to neoplasm.